Decrease in sigma but no increase in striatal dopamine D-4 sites in schizophrenic brains

被引：60

作者：

Helmeste, DM

Tang, SW

Bunney, WE

Potkin, SG

Jones, EG

机构：

[1] UNIV CALIF IRVINE,DEPT ANAT,IRVINE,CA 92697

[2] UNIV CALIF IRVINE,DEPT NEUROBIOL,IRVINE,CA 92697

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 314卷 / 03期

关键词：

sigma receptor; dopamine D-4 receptor; schizophrenia;

D O I：

10.1016/S0014-2999(96)00702-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[H-3]Nemonapride differentially defines sigma and dopamine receptor sites depending upon assay conditions. In post-mortem schizophrenic brain tissues, [H-3]nemonapride-labeled sigma receptor binding is decreased compared to matched normal controls. No striatal dopamine D-4/D-4-like receptor differential was observed between the schizophrenic or control tissues, using the [H-3]nemonapride minus [H-3]raclopride subtraction method.

引用

收藏

页码：R3 / R5

页数：3

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