Synaptic function of cholinergic-specific chol-1α ganglioside

被引：18

作者：

Ando, S ^{[1
]}

Tanaka, Y

Kobayashi, S

Fukui, F

Iwamoto, M

Waki, H

Tai, T

Hirabayashi, Y

机构：

[1] Tokyo Metropolitan Inst Gerontol, Neuronal Funct Res Grp, Div Neurosci & Brain Funct, Itabashi Ku, Tokyo 1730015, Japan

[2] Tokyo Metropolitan Inst Med Sci, Dept Tumor Immunol, Bunkyo Ku, Tokyo 113, Japan

[3] RIKEN, Brain Sci Inst, Frontier Res Program, Neuronal Circuit Membrane Res Grp, Wako, Saitama 35101, Japan

来源：

NEUROCHEMICAL RESEARCH | 2004年 / 29卷 / 04期

关键词：

choline uptake; acetylcholine synthesis; ganglioside; memory; learning;

D O I：

10.1023/B:NERE.0000018860.75734.a7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The function of a cholinergic-specific ganglioside, Chol-1alpha, was investigated. The release of acetylcholine from synaptosomes was inhibited by anti-Chol-1alpha monoclonal antibody but not by monoclonal antibodies against other brain gangliosides tested. Chol-1alpha ganglioside stimulated the high-affinity choline uptake by synaptosomes and consequently enhanced acetylcholine synthesis, resulting in an increased release of acetylcholine from synaptosomes. The memory and learning abilities of rats given anti-Chol-1alpha antibody were remarkably suppressed. These in vitro and in vivo studies suggest that Chol-1alpha ganglioside plays a pivotal role in cholinergic synaptic transmission and participates in cognitive function.

引用

页码：857 / 867

页数：11

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