Acupuncture enhances cell proliferation in dentate gyrus of maternally-separated rats

被引：30

作者：

Park, HJ

Lim, S

Lee, HS

Lee, HJ

Yoo, YM

Lee, HJ

Kim, SA

Yin, CS

Seo, JC

Chung, JH

机构：

[1] Kyung Hee Univ, Coll Med, Kohwang Med Res Inst, Dept Pharmacol, Seoul 130701, South Korea

[2] Kyung Hee Univ, Coll Oriental Med, Dept Meridian & Acupuncture, Seoul 130701, South Korea

[3] Kyung Hee Univ, Grad Sch EW Med Sci, Dept Acupuncture & Meridianol, Yongin 449701, Kyonggi, South Korea

[4] Dong Eui Univ, Coll Oriental Med, Dept Acupuncture & Moxibust, Busanjin 614714, Busan, South Korea

来源：

NEUROSCIENCE LETTERS | 2002年 / 319卷 / 03期

关键词：

acupuncture; maternal separation; cell proliferation; dentate gyrus; 5-bromo-2 '-deoxyuridine;

D O I：

10.1016/S0304-3940(01)02581-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Maternal separation in early life can increase vulnerability to neuropsychiatric disorders over the lifespan. To investigate the effect of acupuncture on cell proliferation in the dentate gyrus (DG), 5-bromo-2'-deoxyuridine (BrdU)-immunohistochemistry was performed in maternally-separated rat pups. Maternal separation, for 7 days from postnatal day 14, induced a significant decrease of BrdU-immunoreactive cells in DG; while acupuncture treatment at acupoint Shen-men (HT7), at the end of the transverse crease of the ulnar wrist, resulted in the significant increase in the number of BrdU-positive cells in DG. However, acupuncture at acupoint ST36, near the knee joint; produced no increase in the number of BrdU-positive cells. These findings indicate that acupuncture at acupoint HT7 appears to stimulate cell proliferation, and we suggested that acupuncture may be useful in the treatment of diseases related to maternal separation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：153 / 156

页数：4

共 21 条

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