Introns in UTRs: Why we should stop ignoring them

被引：96

作者：

Bicknell, Alicia A.

Cenik, Can

Chua, Hon N. ^{[2
]}

Roth, Frederick P. ^{[2
]}

Moore, Melissa J. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA

[2] Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON, Canada

来源：

BIOESSAYS | 2012年 / 34卷 / 12期

关键词：

ALREX; intron; nonsense-mediated decay; 3'-UTR; 5'-UTR; MESSENGER-RNA DECAY; NONSENSE-MEDIATED DECAY; OPEN READING FRAMES; GENE-EXPRESSION; QUALITY-CONTROL; TRANSCRIPTS; COMPLEX; IDENTIFICATION; SURVEILLANCE; PROTEINS;

D O I：

10.1002/bies.201200073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although introns in 5'- and 3'-untranslated regions (UTRs) are found in many protein coding genes, rarely are they considered distinctive entities with specific functions. Indeed, mammalian transcripts with 3'-UTR introns are often assumed nonfunctional because they are subject to elimination by nonsense-mediated decay (NMD). Nonetheless, recent findings indicate that 5'- and 3'-UTR intron status is of significant functional consequence for the regulation of mammalian genes. Therefore these features should be ignored no longer.

引用

页码：1025 / 1034

页数：10

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