Proton magnetic resonance spectroscopy of vascular- and Alzheimer-type dementia

被引：41

作者：

Kattapong, VJ

Brooks, WM

Wesley, MH

Kodituwakku, PW

Rosenberg, GA

机构：

[1] UNIV NEW MEXICO,SCH MED,DEPT NEUROL,ALBUQUERQUE,NM 87131

[2] UNIV NEW MEXICO,SCH MED,DEPT PSYCHIAT,ALBUQUERQUE,NM 87131

[3] UNIV NEW MEXICO,SCH MED,CTR NON INVAS DIAG,ALBUQUERQUE,NM 87131

[4] VET AFFAIRS MED CTR,NEUROL SERV,ALBUQUERQUE,NM

来源：

ARCHIVES OF NEUROLOGY | 1996年 / 53卷 / 07期

关键词：

D O I：

10.1001/archneur.1996.00550070116019

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia. Design end Subjects: Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia. Results: The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P<.02). Conclusion: Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.

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页码：678 / 680

页数：3

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