Desulfurization of Thioamides into Amides with H2O2/ZrCl4 Reagent System

被引：28

作者：

Bahrami, Kiumars ^{[1
,2
]}

Khodaei, Mohammad Mehdi ^{[1
,2
]}

Tirandaz, Yeganeh ^{[1
]}

机构：

[1] Razi Univ, Dept Chem, Kermanshah 67149, Iran

[2] Razi Univ, NNRC, Kermanshah 67149, Iran

来源：

SYNTHESIS-STUTTGART | 2009年 / 03期

关键词：

deprotection; thioamides; amides; desulfurization; hydrogen peroxide; THIOCARBONYL COMPOUNDS; DIMETHYLSULFOXIDE OXIDATIONS; ORGANOSULFUR COMPOUNDS; SELECTIVE CONVERSION; CATALYZED CONVERSION; EFFICIENT; ACID; SELENOPHOSPHORYL; THIOPHOSPHORYL; TRANSFORMATION;

D O I：

10.1055/s-0028-1083314

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hydrogen peroxide/zirconium(IV) chloride reagent system has been used as a new and efficient reagent for the deprotection/desulfurization of thioamides to amides. This system is reasonably general and can be applied to the conversion of several thioamides to the corresponding amides. The salient features of this protocol are short reaction times, good chemoselectivity, cleaner reaction profiles, and simple workup that precludes the use of toxic solvents.

引用

页码：369 / 371

页数：3

共 23 条

[1] Selective oxidation of sulfides to sulfoxides and sulfones using hydrogen peroxide (H2O2) in the presence of zirconium tetrachloride [J].