Gold nanorod-sensitized cell death: Microscopic observation of single living cells irradiated by pulsed near-infrared laser light in the presence of gold nanorods

被引：96

作者：

Takahashi, Hironobu

Niidome, Takuro

Nariai, Ayuko

Niidome, Yasuro

Yamada, Sunao

机构：

[1] Kyushu Univ, Grad Sch Engn, Dept Mat Phys & Chem, Nishi Ku, Fukuoka 8190395, Japan

[2] Kyushu Univ, Fac Engn, Dept Appl Chem, Nishi Ku, Fukuoka 8190395, Japan

[3] Ctr Future Chem, Nishi Ku, Fukuoka 8190395, Japan

来源：

CHEMISTRY LETTERS | 2006年 / 35卷 / 05期

关键词：

D O I：

10.1246/cl.2006.500

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pulsed near-infrared (near-IR) laser irradiation damaged cultured cells in the presence of phosphatidylcholine- passivated gold nanorods (PC-NRs). When single cells were irradiated with a focused pulsed near-IR laser, photoreaction of the PC-NRs caused damage within a very small area around the PC-NRs, and achieved selective cell death of single cells.

引用

收藏

页码：500 / 501

页数：2

相关论文

共 18 条

[1] Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro [J].

Carvalho, M ;

Remiao, F ;

Milhazes, N ;

Borges, F ;

Fernandes, E ;

Monteiro, MD ;

Gonçalves, MJ ;

Seabra, V ;

Amado, F ;

Carvalho, F ;

Bastos, ML .

CHEMICAL RESEARCH IN TOXICOLOGY, 2004, 17 (05) :623-632

[2] Highly efficient, wavelength-tunable, gold nanoparticle based optothermal nanoconvertors [J].

Chou, CH ;

Chen, CD ;

Wang, CRC .

JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (22) :11135-11138

[3] Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity [J].

Connor, EE ;

Mwamuka, J ;

Gole, A ;

Murphy, CJ ;

Wyatt, MD .

SMALL, 2005, 1 (03) :325-327

[4] Hybrid microgels photoresponsive in the near-infrared spectral range [J].

Gorelikov, I ;

Field, LM ;

Kumacheva, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (49) :15938-15939

[5] Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance [J].

Hirsch, LR ;

Stafford, RJ ;

Bankson, JA ;

Sershen, SR ;

Rivera, B ;

Price, RE ;

Hazle, JD ;

Halas, NJ ;

West, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13549-13554

[6] Nondestructive isolation of single cultured animal cells by femtosecond laser-induced shockwave [J].

Hosokawa, Y ;

Takabayashi, H ;

Miura, S ;

Shukunami, C ;

Hiraki, Y ;

Masuhara, H .

APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 2004, 79 (4-6) :795-798

[7] Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods [J].

Huang, XH ;

El-Sayed, IH ;

Qian, W ;

El-Sayed, MA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (06) :2115-2120

[8] Imaging of surface plasmon and ultrafast dynamics in gold nanorods by near-field microscopy [J].

Imura, K ;

Nagahara, T ;

Okamoto, H .

JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (42) :16344-16347

[9] Dependence of the enhanced optical scattering efficiency relative to that of absorption for gold metal nanorods on aspect ratio, size, end-cap shape, and medium refractive index [J].

Lee, KS ;

El-Sayed, MA .

JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (43) :20331-20338

[10] Gold nanorod bioconjugates [J].

Liao, HW ;

Hafner, JH .

CHEMISTRY OF MATERIALS, 2005, 17 (18) :4636-4641