LFG: An anti-apoptotic gene that provides protection from Fas-mediated cell death

被引：110

作者：

Somia, NV ^{[1
]}

Schmitt, MJ ^{[1
]}

Vetter, DE ^{[1
]}

Van Antwerp, D ^{[1
]}

Heinemann, SF ^{[1
]}

Verma, IM ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 22期

关键词：

D O I：

10.1073/pnas.96.22.12667

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Programmed cell death regulates a number of biological phenomena. and the apoptotic signal must itself be tightly controlled to avoid inappropriate cell death. We established a genetic screen to search for molecules that inhibit the apoptotic: signal from the Fas receptor. Here we report the isolation of a gene. LFG, that protects cells uniquely from Fas but not from the mechanistically related tumor necrosis factor alpha death signal. LFG is widely distributed, but remarkably is highly expressed in the hippocampus. LFC can bind to the Fas receptor, but does not regulate Fas expression or interfere with binding of an agonist antibody. Furthermore LFC does not inhibit binding of FADD to Fas.

引用

页码：12667 / 12672

页数：6

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