Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes

被引：27

作者：

Saito, S ^{[1
]}

Aikawa, R ^{[1
]}

Shiojima, I ^{[1
]}

Nagai, R ^{[1
]}

Yazaki, Y ^{[1
]}

Komuro, I ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan

来源：

FEBS LETTERS | 1999年 / 456卷 / 01期

关键词：

endothelin-1; interleukin-6; leukemia inhibitory factor; atrial natriuretic peptide; brain natriuretic peptide; beta-type myosin heavy chain;

D O I：

10.1016/S0014-5793(99)00936-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We here examined the role of the interleukin-6 (IL-6) family of cytokines in endothelin-l (ET-l)-induced hypertrophic responses using cultured cardiac myocytes of neonatal rats. ET-I induced expression of IL-6 and leukemia inhibitory factor (LIF) genes. ET-l-induced LIF gene expression was abolished by inhibition of protein kinase C activity. ET-1 activated the promoter of atrial natriuretic peptide and P-type myosin heavy chain genes through the tyrosine kinase pathway and IL-6 receptor gp130, These results suggest that the IL-6 family of cytokines mediates ET-l-induced expression of some fetal genes in cardiac myocytes, (C) 1999 Federation of European Biochemical Societies.

引用

页码：103 / 107

页数：5

共 27 条

[1] A role for Ca2+/calmodulin-dependent protein kinase II in the mitogen-activated protein kinase signaling cascade of cultured rat aortic vascular smooth muscle cells [J].

Abraham, ST ;

Benscoter, HA ;

Schworer, CM ;

Singer, HA .

CIRCULATION RESEARCH, 1997, 81 (04) :575-584

[2] SELECTIVE CHANGES IN NATRIURETIC PEPTIDE AND EARLY RESPONSE GENE-EXPRESSION IN ISOLATED RAT ATRIA FOLLOWING STIMULATION BY STRETCH OR ENDOTHELIN-1 [J].

BRUNEAU, BG ;

DEBOLD, AJ .

CARDIOVASCULAR RESEARCH, 1994, 28 (10) :1519-1525

[3] Cloning and characterization of the 5′-flanking region of the human cardiotrophin-1 gene [J].

Erdmann, J ;

Hassfeld, S ;

Kallisch, H ;

Fleck, E ;

Regitz-Zagrosek, V .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 244 (02) :494-497

[4] Oncogenic src, raf, and ras stimulate a hypertrophic pattern of gene expression and increase cell size in neonatal rat ventricular myocytes [J].

Fuller, SJ ;

Gillespie-Brown, J ;

Sugden, PH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) :18146-18152

[5] CYTOKINE-INDUCED EXPRESSION OF LEUKEMIA INHIBITORY FACTOR IN RENAL MESANGIAL CELLS [J].

HARTNER, A ;

STERZEL, RB ;

REINDL, N ;

HOCKE, GM ;

FEY, GH ;

GOPPELTSTRUEBE, M .

KIDNEY INTERNATIONAL, 1994, 45 (06) :1562-1571

[6] N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, A CALMODULIN ANTAGONIST, INHIBITS CELL-PROLIFERATION [J].

HIDAKA, H ;

SASAKI, Y ;

TANAKA, T ;

ENDO, T ;

OHNO, S ;

FUJII, Y ;

NAGATA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4354-4357

[7] CELLULAR MECHANISM OF ACTION BY A NOVEL VASOCONSTRICTOR ENDOTHELIN IN CULTURED RAT VASCULAR SMOOTH-MUSCLE CELLS [J].

HIRATA, Y ;

YOSHIMI, H ;

TAKATA, S ;

WATANABE, TX ;

KUMAGAI, S ;

NAKAJIMA, K ;

SAKAKIBARA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (03) :868-875

[8] ENDOTHELIN-1 INDUCES HYPERTROPHY WITH ENHANCED EXPRESSION OF MUSCLE-SPECIFIC GENES IN CULTURED NEONATAL RAT CARDIOMYOCYTES [J].

ITO, H ;

HIRATA, Y ;

HIROE, M ;

TSUJINO, M ;

ADACHI, S ;

TAKAMOTO, T ;

NITTA, M ;

TANIGUCHI, K ;

MARUMO, F .

CIRCULATION RESEARCH, 1991, 69 (01) :209-215

[9] CYTOKINE SIGNAL-TRANSDUCTION [J].

KISHIMOTO, T ;

TAGA, T ;

AKIRA, S .

CELL, 1994, 76 (02) :253-262

[10]

Kodama H, 1997, CIRC RES, V81, P656

← 1 2 3 →