Cloning and characterization of the 5′-flanking region of the human cardiotrophin-1 gene

被引:8
作者
Erdmann, J
Hassfeld, S
Kallisch, H
Fleck, E
Regitz-Zagrosek, V
机构
[1] Humboldt Univ, Klinikum Rudolf Virchow, Dept Internal Med Cardiol, D-13353 Berlin, Germany
[2] Deutsch Herzzentrum Berlin, D-13353 Berlin, Germany
关键词
cardiotrophin-1 (CT-1); promoter; reportergene assay; COS-7; cells;
D O I
10.1006/bbrc.1998.8311
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To enable the analysis of the regulation of the human cardiotrophin-1 gene expression, the 5'-flanking region of the human cardiotrophin-1 gene was cloned and sequenced. Data bank search revealed several cis-active DNA elements (SP1, CREB, C/EBP, AP1 and AP2 like and GATA) in the proximal 1.1 kb region, Six nested 5-'terminal deletion mutants from -1091/+39 to -218/+39 were fused to a luciferase reportergene and proved to be functionally active after transfection into COS-7 cells. (C) 1998 Academic Press.
引用
收藏
页码:494 / 497
页数:4
相关论文
共 15 条
[1]   INTERLEUKIN-6 IN BIOLOGY AND MEDICINE [J].
AKIRA, S ;
TAGA, T ;
KISHIMOTO, T .
ADVANCES IN IMMUNOLOGY, VOL 54, 1993, 54 :1-78
[2]   A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY [J].
AKIRA, S ;
ISSHIKI, H ;
SUGITA, T ;
TANABE, O ;
KINOSHITA, S ;
NISHIO, Y ;
NAKAJIMA, T ;
HIRANO, T ;
KISHIMOTO, T .
EMBO JOURNAL, 1990, 9 (06) :1897-1906
[3]   REGULATION OF CARDIAC GENE-EXPRESSION DURING MYOCARDIAL GROWTH AND HYPERTROPHY - MOLECULAR STUDIES OF AN ADAPTIVE PHYSIOLOGICAL-RESPONSE [J].
CHIEN, KR ;
KNOWLTON, KU ;
ZHU, H ;
CHIEN, S .
FASEB JOURNAL, 1991, 5 (15) :3037-3046
[4]   MOLECULAR ADVANCES IN CARDIOVASCULAR BIOLOGY [J].
CHIEN, KR .
SCIENCE, 1993, 260 (5110) :916-917
[5]   SYNERGISTIC ACTIVATION BY THE GLUTAMINE-RICH DOMAINS OF HUMAN TRANSCRIPTION FACTOR SP1 [J].
COUREY, AJ ;
HOLTZMAN, DA ;
JACKSON, SP ;
TJIAN, R .
CELL, 1989, 59 (05) :827-836
[6]   AN ERYTHROCYTE-SPECIFIC DNA-BINDING FACTOR RECOGNIZES A REGULATORY SEQUENCE COMMON TO ALL CHICKEN GLOBIN GENES [J].
EVANS, T ;
REITMAN, M ;
FELSENFELD, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) :5976-5980
[7]   The state of the STATs: Recent developments in the study of signal transduction to the nucleus [J].
Horvath, CM ;
Darnell, JE .
CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (02) :233-239
[8]   cDNA cloning of rat cardiotrophin-1 (CT-1): Augmented expression of CT-1 gene in ventricle of genetically hypertensive rats [J].
Ishikawa, M ;
Saito, Y ;
Miyamoto, Y ;
Kuwahara, K ;
Ogawa, E ;
Nakagawa, O ;
Harada, M ;
Masuda, I ;
Nakao, K .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 219 (02) :377-381
[9]   2 TRANSCRIPTIONAL ACTIVATORS, CCAAT-BOX-BINDING TRANSCRIPTION FACTOR AND HEAT-SHOCK TRANSCRIPTION FACTOR, INTERACT WITH A HUMAN HSP70-GENE PROMOTER [J].
MORGAN, WD ;
WILLIAMS, GT ;
MORIMOTO, RI ;
GREENE, J ;
KINGSTON, RE ;
TJIAN, R .
MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (03) :1129-1138
[10]   Human cardiotrophin-1: Protein and gene structure, biological and binding activities, and chromosomal localization [J].
Pennica, D ;
Swanson, TA ;
Shaw, KJ ;
Kuang, WJ ;
Gray, CL ;
Beatty, BG ;
Wood, WI .
CYTOKINE, 1996, 8 (03) :183-189