Synthesis of sialyl Lewis X analogues

被引：10

作者：

Dekany, G

Wright, K

Ward, P

Toth, I

机构：

[1] UNIV LONDON,SCH PHARM,LONDON WC1N 1AX,ENGLAND

[2] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1996年 / 15卷 / 04期

关键词：

D O I：

10.1080/07328309608005661

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sialyl Lewis X (SLe(x)) analogs 2a and 2b were synthesised, where the N-acetyl-D-glucose and the D-galactose units of SLe(x) 1 were replaced with an alkyl and a heteroalkyl spacer. Sulphate ester 6i was also synthesised from alcohol 6b and chlorosulphonic acid. A novel promoter. silver mercaptoethanesulphonate. was used to synthesise alpha-sialosides 2c, 7b and 7c.

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页码：383 / 398

页数：16

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