Umbilical cord blood transplantation: a maturing technology

被引：42

作者：

Oran, Betul ^{[1
]}

Shpall, Elizabeth ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplant & Cellular Therapy, Houston, TX 77030 USA

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2012年

关键词：

HEMATOPOIETIC STEM-CELLS; ACUTE MYELOID-LEUKEMIA; VERSUS-HOST-DISEASE; EX-VIVO; UNRELATED DONORS; BONE-MARROW; PEDIATRIC-PATIENTS; ADULT RECIPIENTS; INTENSITY; ENGRAFTMENT;

D O I：

10.1182/asheducation-2012.1.215

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

The use of umbilical cord blood (CB) as a source of hematopoietic progenitor cells for patients with high-risk hematologic disorders receiving allogeneic hematopoietic cell transplantations (HCTs) has increased significantly. Single-institution and registry studies have shown a decreased relapse rate and an increased transplantation-related mortality rate with similar overall survival rates after allogeneic HCT with CB compared with other donor sources. The transplantation of double CB units has overcome the dose limitation inherent in a single CB unit and thus has markedly extended the use of CB to larger children and adults. Similarly, the use of reduced intensity conditioning in the CB transplantation setting has allowed the treatment of older patients who would be unable to tolerate the myeloablative regimens used in the original CB transplantation protocols.

引用

页码：215 / 222

页数：8

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