Iontophoretic drug delivery

被引:578
作者
Kalia, YN
Naik, A
Garrison, J
Guy, RH
机构
[1] Ctr Interuniv Rech & Enseignement, F-74160 Archamps, France
[2] Univ Geneva, Sch Pharm, CH-1211 Geneva 4, Switzerland
[3] Vyteris Inc, Fair Lawn, NJ USA
关键词
electrically-assisted delivery; iontophoresis; non-invasive; peptide and protein therapeutics; skin; topical; transdermal; transport mechanisms;
D O I
10.1016/j.addr.2003.10.026
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The composition and architecture of the stratum corneum render it a formidable barrier to the topical and transdermal administration of therapeutic agents. The physicochemical constraints severely limit the number of molecules that can be considered as realistic candidates for transdermal delivery. Iontophoresis provides a mechanism to enhance the penetration of hydrophilic and charged molecules across the skin. The principal distinguishing feature is the control afforded by iontophoresis and the ability to individualize therapies. This may become significant as the impact of interindividual variations in protein expression and the effect on drug metabolism and drug efficacy is better understood. In this review we describe the underlying mechanisms that drive iontophoresis and we discuss the impact of key experimental parameters-namely, drug concentration, applied current and pH-on iontophoretic delivery efficiency. We present a comprehensive and critical review of the different therapeutic classes and molecules that have been investigated as potential candidates for iontophoretic delivery. The iontophoretic delivery of peptides and proteins is also discussed. In the final section, we describe the development of the first pre-filled, pre-programmed iontophoretic device, which is scheduled to be commercialized during the course of 2004. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:619 / 658
页数:40
相关论文
共 150 条
[1]   Passive and iontophoretic transdermal penetration of methotrexate [J].
Alvarez-Figueroa, MJ ;
Delgado-Charro, MB ;
Blanco-Méndez, J .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 212 (01) :101-107
[2]   Iontophoretic administration of 2% lidocaine HCl and 1:100,000 epinephrine in humans [J].
Ashburn, MA ;
Gauthier, M ;
Love, G ;
Basta, S ;
Gaylord, B ;
Kessler, K .
CLINICAL JOURNAL OF PAIN, 1997, 13 (01) :22-26
[3]   THE IONTOPHORESIS OF FENTANYL CITRATE IN HUMANS [J].
ASHBURN, MA ;
STREISAND, J ;
ZHANG, J ;
LOVE, G ;
ROWIN, M ;
NIU, S ;
KIEVIT, JK ;
KROEP, JR ;
MERTENS, MJ .
ANESTHESIOLOGY, 1995, 82 (05) :1146-1153
[4]   IONTOPHORETIC DELIVERY OF MORPHINE FOR POSTOPERATIVE ANALGESIA [J].
ASHBURN, MA ;
STEPHEN, RL ;
ACKERMAN, E ;
PETELENZ, TJ ;
HARE, B ;
PACE, NL ;
HOFMAN, AA .
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 1992, 7 (01) :27-33
[5]   TRANSDERMAL IONTOPHORETIC DELIVERY AND DEGRADATION OF VASOPRESSIN ACROSS HUMAN CADAVER SKIN [J].
BANGA, AK ;
KATAKAM, M ;
MITRA, R .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 116 (02) :211-216
[6]   CHARACTERIZATION OF IN-VITRO TRANSDERMAL IONTOPHORETIC DELIVERY OF INSULIN [J].
BANGA, AK ;
CHIEN, YW .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1993, 19 (16) :2069-2087
[7]   Iontophoresis of nafarelin across human skin in vitro [J].
Bayon, AMR ;
Guy, RH .
PHARMACEUTICAL RESEARCH, 1996, 13 (05) :798-800
[8]   Effect of penetration enhancers and iontophoresis on the FT-IR spectroscopy and LHRH permeability through porcine skin [J].
Bhatia, KS ;
Gao, S ;
Singh, J .
JOURNAL OF CONTROLLED RELEASE, 1997, 47 (01) :81-89
[9]   Effect of linolenic acid ethanol or limonene ethanol and iontophoresis on the in vitro percutaneous absorption of LHRH and ultrastructure of human epidermis [J].
Bhatia, KS ;
Singh, J .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 180 (02) :235-250
[10]   Synergistic effect of iontophoresis and a series of fatty acids on LHRH permeability through porcine skin [J].
Bhatia, KS ;
Singh, J .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 87 (04) :462-469