Formation of phostonic acids during the reduction of azidonucleosidephosphonic acids

被引：7

作者：

Morr, M

Kakoschke, C

Ernst, L

机构：

[1] Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany

[2] Tech Univ Carolo Wilhelmina Braunschweig, Dept Chem, D-38092 Braunschweig, Germany

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 50期

关键词：

nucleosides; phosphonic acids and derivatives; cyclonucleotide analogs;

D O I：

10.1016/S0040-4039(01)01919-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reduction of 5'-azido-3',5'-dideoxy-3'-(phosphorylmethyl)nucleosides, either with H-2/Pd/C or with dithiothreitol, leads to cyclic phosphonate esters (phostonic acids) in addition to the desired 5'-amino compounds. The phostonic acids are obtained as the main products when a 20-fold excess of dithiothreitol is used. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8841 / 8843

页数：3

共 9 条

[1] HOMONUCLEOSIDE PHOSPHONIC-ACIDS .1. A GENERAL-SYNTHESIS OF ISOSTERIC PHOSPHONATE ANALOGS OF NUCLEOSIDE 3'-PHOSPHATES [J].