SYNTHESIS OF PYROPHOSPHONIC ACID ANALOGS OF FARNESYL PYROPHOSPHATE

被引：23

作者：

VALENTIJN, ARPM ^{[1
]}

VANDENBERG, O ^{[1
]}

VANDERMAREL, GA ^{[1
]}

COHEN, LH ^{[1
]}

VANBOOM, JH ^{[1
]}

机构：

[1] TNO,INST AGEING & VASC RES,GAUBIUS LAB,2300 AK LEIDEN,NETHERLANDS

来源：

TETRAHEDRON | 1995年 / 51卷 / 07期

关键词：

D O I：

10.1016/0040-4020(94)01083-C

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of four new analogues (i.e. 3-6) of farnesyl pyrophosphate (FPP), which may function as inhibitor of squalene synthase, is described. Compounds 3 and 4 were readily accessible by reaction of farnesal with diethyl phosphite or dimethyl lithiomethylphosphonate, respectively, followed by condensation of the resulting alcohols with diethyl phosphonomethyl triflate. The preparation of 5 and 6 was accomplished by alkylation of bis(diethyl phosphonomethyl) ether or tetraethyl methylenebisphosphonate, respectively, with farnesyl bromide.

引用

页码：2099 / 2108

页数：10

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