Pulmonary protective effects of hyberbaric oxygen and N-acetylcysteine treatment in necrotizing pancreatitis

被引：9

作者：

Balkan, A ^{[1
]}

Balkan, M

Yasar, M

Korkmaz, A

Erdem, O

Kiliç, S

Kutsal, O

Bilgic, H

机构：

[1] Gulhane Mil Med Acad, Gulhane Mil Med Acad, Dept Pulm Med, TR-06013 Ankara, Turkey

[2] Gulhane Mil Med Acad, Gulhane Mil Med Acad, Dept Surg, TR-06013 Ankara, Turkey

[3] Gulhane Mil Med Acad, Gulhane Mil Med Acad, Dept Physiol, TR-06013 Ankara, Turkey

[4] Gulhane Mil Med Acad, Gulhane Mil Med Acad, Dept Pharmacol, TR-06013 Ankara, Turkey

[5] Ankara Univ, Dept Pathol, TR-06100 Ankara, Turkey

来源：

PHYSIOLOGICAL RESEARCH | 2006年 / 55卷 / 01期

关键词：

acute necrotizing pancreatitis; lung injury; hyperbaric oxygen; reactive oxygen species;

D O I：

10.33549/physiolres.930765

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The purpose of this study is to analyze the protective effect of combining N-acetylcysteine (NAC) and hyberbaric oxygen (HBO) treatment in the lung tissue during acute pancreatitis. Sixty Sprague-Dawley male rats were randomly divided into five groups; Group I; Control group (n=12), Group II; pancreatitis group (n=12), Group III; pancreatitis + NAC treatment group (n=12), Group IV; pancreatitis + HBO treatment group (n=12), Group V; pancreatitis + HBO + NAC treatment group (n=12). HBO was applied postoperatively for 5 days, twice a day at 2.5 fold absolute atmospheric pressure for 90 min. Lung tissue was obtained for measuring malondialdehyde (MDA), superoxide dismutase (Cu/Zn-SOD) and glutathione peroxidase (GSH-Px) levels along with histopathological tissue examinations. This study showed that all three treated groups (HBO alone, NAC alone and combined HBO+NAC treatment) had pulmonary protective effects during acute necrotizing pancreatitis.

引用

页码：25 / 31

页数：7

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