Osteogenic activity and antibacterial effects on titanium surfaces modified with Zn-incorporated nanotube arrays

被引：294

作者：

Huo, Kaifu ^{[1
,2
]}

Zhang, Xuming ^{[2
]}

Wang, Hairong ^{[1
]}

Zhao, Lingzhou ^{[3
]}

Liu, Xuanyong ^{[4
]}

Chu, Paul K. ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, WNLO, Wuhan 430074, Peoples R China

[2] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China

[3] Fourth Mil Med Univ, Sch Stomatol, Dept Periodontol & Oral Med, Xian 710032, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

BIOMATERIALS | 2013年 / 34卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Mesenchymal stem cells; Titania nanotubes; Zinc; Antibacterial property; Osteogenic differentiation; OSTEOBLAST FUNCTIONS; ZINC; BONE; ACTIVATION; HYDROXYAPATITE; ADHESION; OSSEOINTEGRATION; EXPRESSION; COATINGS;

D O I：

10.1016/j.biomaterials.2013.01.071

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Titanium implants having enhanced osteogenic activity and antibacterial property are highly desirable for the prevention of implant associated infection and promotion of osseointegration. In this study, coatings containing titania nanotubes (NTs) incorporated with zinc (NT-Zn) are produced on Ti implants by anodization and hydrothermal treatment in Zn containing solutions. The amount of incorporated Zn can be adjusted by varying the structural parameters such as the nanotube diameter and length as well as hydrothermal treatment time. The suitable NT-Zn coatings with good intrinsic antibacterial properties can prevent post-operation infection. Excellent osteogenesis inducing ability in the absence of extraneous osteogenic supplements is demonstrated and the ERK1/2 signaling is found to be involved. The NT-Zn structure which is simple, stable, and easy to produce and scale up has immense potential in bone implant applications. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3467 / 3478

页数：12

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