AKAP mediated signal transduction

被引：259

作者：

Michel, JJC ^{[1
]}

Scott, JD ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Howard Hughes Med Inst, Portland, OR 97201 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2002年 / 42卷

关键词：

PKA; A-kinase anchoring protein; multivalent signaling platforms; cAMP; compartmentalization;

D O I：

10.1146/annurev.pharmtox.42.083101.135801

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Compartmentalization of cyclic AMP-dependent protein kinase (PKA) is achieved through association with A-kinase anchoring proteins (AKAPs). AKAPs are a group of structurally diverse proteins with the common function of binding to the regulatory subunit of PKA and confining the holoenzyme to discrete locations within the cell. This mode of regulation ensures that PKA is exposed to isolated cAMP gradients, which allows for efficient catalytic activation and accurate substrate selection. Several AKAPs coordinate multiple members of signaling cascades, effectively assembling upstream activators and downstream effectors within the same macromolecular complex. Consequently, AKAPs may serve as points of integration for numerous signaling pathways. This review details the most recent advances in our understanding of the various biological functions dependent upon AKAP-anchored signaling complexes.

引用

页码：235 / 257

页数：23

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