学术探索
学术期刊
新闻热点
数据分析
智能评审

Potent antibody therapeutics by design

被引：824
作者：
Carter, PJ [1 ]
机构：
[1] Genet Incorp, Dept Antibody Technol, Bothell, WA 98021 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 05期
关键词：
D O I：
10.1038/nri1837
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antibodies constitute the most rapidly growing class of human therapeutics and the second largest class of drugs after vaccines. The generation of potent antibody therapeutics, which I review here, is an iterative design process that involves the generation and optimization of antibodies to improve their clinical potential.
引用
收藏
页码：343 / 357
页数：15
相关论文
共 144 条
  • [1] Adams GP, 2001, CANCER RES, V61, P4750
  • [2] Monoclonal antibody therapy of cancer
    Adams, GP
    Weiner, LM
    [J]. NATURE BIOTECHNOLOGY, 2005, 23 (09) : 1147 - 1157
  • [3] Adams GP, 1998, CANCER RES, V58, P485
  • [4] ALEGRE ML, 1994, TRANSPLANTATION, V57, P1537
  • [5] Production and characterization of mice transgenic for the A and B isoforms of human FcγRIII
    Amoroso, AR
    Alpaugh, RK
    Barth, MW
    McCall, AM
    Weiner, LM
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 1999, 48 (08) : 443 - 455
  • [6] Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin
    Austin, CD
    De Mazière, AM
    Pisacane, PI
    van Dijk, SM
    Eigenbrot, C
    Sliwkowski, MX
    Klumperman, J
    Scheller, RH
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (12) : 5268 - 5282
  • [7] A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities
    Babcook, JS
    Leslie, KB
    Olsen, OA
    Salmon, RA
    Schrader, JW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) : 7843 - 7848
  • [8] Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator
    Baker, KP
    Edwards, BM
    Main, SH
    Choi, GH
    Wager, RE
    Halpern, WG
    Lappin, PB
    Riccobene, T
    Abramian, D
    Sekut, L
    Sturm, B
    Poortman, C
    Minter, RR
    Dobson, CL
    Williams, E
    Carmen, S
    Smith, R
    Roschke, V
    Hilbert, DM
    Vaughan, TJ
    Albert, VR
    [J]. ARTHRITIS AND RHEUMATISM, 2003, 48 (11): : 3253 - 3265
  • [9] Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library
    Begent, RHJ
    Verhaar, MJ
    Chester, KA
    Casey, JL
    Green, AJ
    Napier, MP
    HopeStone, LD
    Cushen, N
    Keep, PA
    Johnson, CJ
    Hawkins, RE
    Hilson, AJW
    Robson, L
    [J]. NATURE MEDICINE, 1996, 2 (09) : 979 - 984
  • [10] THE GENERATION OF A HUMANIZED, NON-MITOGENIC CD3 MONOCLONAL-ANTIBODY WHICH RETAINS INVITRO IMMUNOSUPPRESSIVE PROPERTIES
    BOLT, S
    ROUTLEDGE, E
    LLOYD, I
    CHATENOUD, L
    POPE, H
    GORMAN, SD
    CLARK, M
    WALDMANN, H
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (02) : 403 - 411
12345678910