Potent antibody therapeutics by design

被引：833

作者：

Carter, PJ ^{[1
]}

机构：

[1] Genet Incorp, Dept Antibody Technol, Bothell, WA 98021 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 05期

关键词：

D O I：

10.1038/nri1837

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies constitute the most rapidly growing class of human therapeutics and the second largest class of drugs after vaccines. The generation of potent antibody therapeutics, which I review here, is an iterative design process that involves the generation and optimization of antibodies to improve their clinical potential.

引用

页码：343 / 357

页数：15

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