Microwave-Enhanced Solid-Phase Synthesis of N,N′-Linked Aliphatic Oligoureas and Related Hybrids

被引：46

作者：

Douat-Casassus, Celine ^{[1
]}

Pulka, Karolina ^{[1
]}

Claudon, Paul ^{[1
]}

Guichard, Gilles ^{[1
]}

机构：

[1] Univ Bordeaux, Inst Europeen Chim & Biol, CNRS, UMR 5248, F-33607 Pessac, France

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 12期

关键词：

PEPTIDE-SYNTHESIS; DERIVATIVES; FOLDAMERS; DESIGN; ACID; AZIDES; HELIX;

D O I：

10.1021/ol3012106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient microwave-assisted solid-phase method for the synthesis of N,N'-linked oligoureas and related amide/urea hybrid oligomers, featuring the use of succinimidyl (2-azido-2-substituted ethyl) carbamate monomers, is reported. The rate enhancement of urea formation under microwave irradiation combined with the mild conditions of the phosphine-based azide reduction makes this approach very effective for routine synthesis of oligoureas and possibly for library production.

引用

页码：3130 / 3133

页数：4

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