Azidopeptide nucleic acid. An alternative strategy for solid-phase peptide nucleic acid (PNA) synthesis

被引：39

作者：

Debaene, F ^{[1
]}

Winssinger, N ^{[1
]}

机构：

[1] Univ Strasbourg, Inst Sci & Ingn Supramol, F-67000 Strasbourg, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol0358408

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical and efficient method for PNA synthesis using an azide group to mask the N-terminus is reported. The deprotection was carried out in 5 min, while couplings were complete within 60 min. The near neutral conditions of the phosphine deprotection combined with the base-free coupling using hydroxybenzotriazole-activated monomers make this approach very mild.

引用

页码：4445 / 4447

页数：3

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