Orthogonal N,N-deprotection strategies of β-amino esters

被引：37

作者：

Bull, SD ^{[1
]}

Davies, SG ^{[1
]}

Kelly, PM ^{[1
]}

Gianotti, M ^{[1
]}

Smith, AD ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 23期

关键词：

D O I：

10.1039/b106389h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta -Amino esters derived from the stereoselective conjugate addition of homochiral lithium N-benzyl-N-alpha -methyl-4-methoxybenzylamide to alpha,beta -unsaturated esters may be orthogonally mono-N-deprotected under either oxidative or acid-promoted reaction conditions. Further oxidative deprotection affords beta -amino acids or beta -lactams.

引用

页码：3106 / 3111

页数：6

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