Mechanisms of microRNA deregulation in human cancer

被引：296

作者：

Deng, Shan ^{[1
]}

Calin, George Adrian ^{[4
]}

Croce, Carlo M. ^{[5
,6
,7
]}

Coukos, George ^{[1
,2
,3
]}

Zhang, Lin ^{[1
,2
]}

机构：

[1] Univ Penn, Ctr Res Early Detect & Cure Ovarian Canc, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA

[3] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Dept Canc Genet, Houston, TX 77030 USA

[5] Ohio State Univ, Dept Mol Virol, Columbus, OH 43210 USA

[6] Ohio State Univ, Dept Immunol, Columbus, OH 43210 USA

[7] Ohio State Univ, Dept Med Genet, Columbus, OH 43210 USA

来源：

CELL CYCLE | 2008年 / 7卷 / 17期

关键词：

microRNA; non-coding RNA; gene expression; cancer;

D O I：

10.4161/cc.7.17.6597

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

microRNAs (miRNAs) are an abundant class of small non-coding RNAs that function as gene regulators. Although deregulation of miRNA expression is involved in the initiation and progression of tumorigenesis, the underlying mechanisms of miRNA deregulation in human cancer are still largely unknown. Increasing evidence indicates that transcriptional deregulations, epigenetic alterations, mutations, DNA copy number abnormalities and defects in the miRNA biogenesis machinery might contribute to miRNA deregulation in human cancer. A clearer understanding of the mechanisms involved in miRNA deregulation in human cancer will contribute greatly to the development of new miRNA-based strategies in cancer diagnosis and treatment.

引用

页码：2643 / 2646

页数：4

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