RNA pseudoknots and the regulation of protein synthesis

被引：43

作者：

Brierley, Ian ^{[1
]}

Gilbert, Robert J. C. ^{[2
]}

Pennell, Simon ^{[3
]}

机构：

[1] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

[2] Univ Oxford, Div Struct Biol, Oxford OX3 7BN, England

[3] MRC Natl Inst Med Res, Div Mol Struct, London NW7 1AA, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

frameshift; internal ribosome entry site (IRES); protein synthesis; ribosome; RNA pseudoknot; translation;

D O I：

10.1042/BST0360684

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA pseudoknots are structural elements found in almost all classes of RNA. Pseudoknots form when a single-stranded region in the loop of a hairpin base-pairs with a stretch of complementary nucleotides elsewhere in the RNA chain. This simple folding strategy is capable of generating a large number of stable three-dimensional folds that display a diverse range of highly specific functions in a variety of biological processes. The present review focuses on pseudoknots that act in the regulation of protein synthesis using cellular and viral examples to illustrate their versatility. Emphasis is placed on structurally well-defined pseucloknots that play a role in internal ribosome entry, autoregulation of initiation, ribosomal frameshifting during elongation and trans-translation.

引用

页码：684 / 689

页数：6

共 49 条

[1] Structural studies of the RNA pseudoknot required for readthrough of the gag-termination codon of murine leukemia virus [J].