Viral RNA pseudoknots: versatile motifs in gene expression and replication

被引：167

作者：

Brierley, Ian

Pennell, Simon

Gilbert, Robert J. C.

机构：

[1] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

[2] Natl Inst Med Res, Div Mol Struct, London NW7 1AA, England

[3] Univ Oxford, Henry Wellcome Bldg Genom Med, Div Struct Biol, Oxford OX3 7BN, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrmicro1704

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RNA pseudoknots are structural elements found in almost all classes of RNA. First recognized in the genomes of plant viruses, they are now established as a widespread motif with diverse functions in various biological processes. This Review focuses on viral pseudoknots and their role in virus gene expression and genome replication. Although emphasis is placed on those well defined pseudoknots that are involved in unusual mechanisms of viral translational initiation and elongation, the broader roles of pseudoknots are also discussed, including comparisons with relevant cellular counterparts. The relationship between RNA pseudoknot structure and function is also addressed.

引用

页码：598 / 610

页数：13

共 150 条

[1] Structural studies of the RNA pseudoknot required for readthrough of the gag-termination codon of murine leukemia virus [J].