Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene

被引：4

作者：

Artandi, SE ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Div Hematol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Canc Biol Program, Stanford, CA 94305 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 05期

关键词：

D O I：

10.1084/jem.20060849

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Telomerase, the enzyme that elongates our telomeres, is crucial for cancer development based on extensive analyses of human cells, human cancers, and mouse models. New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MDV), an oncogenic herpesvirus of chickens, promotes tumor formation. These findings highlight the importance of telomerase in cancer and raise new questions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.

引用

页码：1143 / 1145

页数：3

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