Novel antiplatelet constituents from Formosan Moraceous plants

被引:81
作者
Lin, CN
Lu, CM
Lin, HC
Fang, SC
Shieh, BJ
Hsu, MF
Wang, JP
Ko, FN
Teng, CM
机构
[1] KAOHSIUNG MED COLL, SCH TECHNOL & MED SCI, KAOHSIUNG 807, TAIWAN
[2] CHUNG YUAN CHRISTIAN UNIV, GRAD INST CHEM, CHUNGLI 320, TAIWAN
[3] CHINA MED COLL, DEPT BIOCHEM, TAICHUNG 400, TAIWAN
[4] TAICHUNG VET GEN HOSP, DEPT MED RES, TAICHUNG 407, TAIWAN
[5] NATL TAIWAN UNIV, COLL MED, INST PHARMACOL, TAIPEI 100, TAIWAN
来源
JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 09期
关键词
D O I
10.1021/np960376j
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Sixteen constituents from Formosan Moraceous plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and braussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. Of the compounds tested, broussochalcone A exhibited the most potent inhibition of platelet aggregation induced by AA (IC50 = 6.8 mu M). The antiplatelet effects of cycloheterophyllin, broussochalcone A, kazinol B, broussoaurone A, and broussoflavonol F are partially due to an inhibitory effect on cyclooxygenase.
引用
收藏
页码:834 / 838
页数:5
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