Novel antiplatelet constituents from Formosan Moraceous plants

被引：81

作者：

Lin, CN

Lu, CM

Lin, HC

Fang, SC

Shieh, BJ

Hsu, MF

Wang, JP

Ko, FN

Teng, CM

机构：

[1] KAOHSIUNG MED COLL, SCH TECHNOL & MED SCI, KAOHSIUNG 807, TAIWAN

[2] CHUNG YUAN CHRISTIAN UNIV, GRAD INST CHEM, CHUNGLI 320, TAIWAN

[3] CHINA MED COLL, DEPT BIOCHEM, TAICHUNG 400, TAIWAN

[4] TAICHUNG VET GEN HOSP, DEPT MED RES, TAICHUNG 407, TAIWAN

[5] NATL TAIWAN UNIV, COLL MED, INST PHARMACOL, TAIPEI 100, TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 09期

关键词：

D O I：

10.1021/np960376j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sixteen constituents from Formosan Moraceous plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and braussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. Of the compounds tested, broussochalcone A exhibited the most potent inhibition of platelet aggregation induced by AA (IC50 = 6.8 mu M). The antiplatelet effects of cycloheterophyllin, broussochalcone A, kazinol B, broussoaurone A, and broussoflavonol F are partially due to an inhibitory effect on cyclooxygenase.

引用

页码：834 / 838

页数：5

共 15 条

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