Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

被引：1064

作者：

Thorleifsson, Gudmar ^{[1
]}

Walters, G. Bragi ^{[1
]}

Gudbjartsson, Daniel F. ^{[1
]}

Steinthorsdottir, Valgerdur ^{[1
]}

Sulem, Patrick ^{[1
]}

Helgadottir, Anna ^{[1
]}

Styrkarsdottir, Unnur ^{[1
]}

Gretarsdottir, Solveig ^{[1
]}

Thorlacius, Steinunn ^{[1
]}

Jonsdottir, Ingileif ^{[1
,2
]}

Jonsdottir, Thorbjorg ^{[1
]}

Olafsdottir, Elinborg J. ^{[3
]}

Olafsdottir, Gudridur H. ^{[3
]}

Jonsson, Thorvaldur ^{[2
,4
]}

Jonsson, Frosti ^{[1
]}

Borch-Johnsen, Knut ^{[5
,6
]}

Hansen, Torben ^{[5
,7
,8
]}

Andersen, Gitte ^{[5
]}

Jorgensen, Torben

Lauritzen, Torsten ^{[9
]}

Aben, Katja K. ^{[10
]}

Verbeek, Andre L. M. ^{[11
]}

Roeleveld, Nel ^{[11
]}

Kampman, Ellen ^{[11
]}

Yanek, Lisa R. ^{[12
]}

Becker, Lewis C. ^{[12
]}

Tryggvadottir, Laufey ^{[12
]}

Rafnar, Thorunn ^{[1
]}

Becker, Diane M. ^{[12
]}

Gulcher, Jeffrey ^{[1
]}

Kiemeney, Lambertus A. ^{[10
,11
,13
]}

Pedersen, Oluf ^{[5
,6
,8
]}

Kong, Augustine ^{[1
]}

Thorsteinsdottir, Unnur ^{[1
,2
]}

Stefansson, Kari ^{[1
,2
]}

机构：

[1] deCODE Genet, IS-101 Reykjavik, Iceland

[2] Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland

[3] Iceland Canc Registry, IS-105 Reykjavik, Iceland

[4] Univ Hosp, Dept Surg, IS-101 Reykjavik, Iceland

[5] Steno Diabet Ctr, DK-2820 Gentofte, Denmark

[6] Univ Aarhus, Fac Hlth Sci, DK-8000 Aarhus, Denmark

[7] Glostrup Univ Hosp, Res Ctr Prevent & Hlth, DK-2600 Glostrup, Denmark

[8] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark

[9] Univ Aarhus, Dept Gen Med Practice, DK-8000 Aarhus, Denmark

[10] Comprehens Canc Ctr E, NL-6500 HB Nijmegen, Netherlands

[11] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol & Biostat, NL-6500 HB Nijmegen, Netherlands

[12] Johns Hopkins Univ, Sch Med, Johns Hopkins Sibling & Family Heart Study, Baltimore, MD 21287 USA

[13] Radboud Univ Nijmegen, Dept Urol, NL-6500 HB Nijmegen, Netherlands

来源：

NATURE GENETICS | 2009年 / 41卷 / 01期

关键词：

BODY-MASS INDEX; METABOLIC SYNDROME; NEURITE OUTGROWTH; GENETIC-VARIATION; ALPHA GENE; PROTEIN; WEIGHT; POLYMORPHISM; METAANALYSIS; OVERWEIGHT;

D O I：

10.1038/ng.274

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.

引用

页码：18 / 24

页数：7

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