Ion channels that control fertility in mammalian spermatozoa

被引：118

作者：

Navarro, Betsy ^{[1
]}

Kirichok, Yuriy ^{[1
]}

Chung, Jean-Ju ^{[1
]}

Clapham, David E. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst,Dept Cardiol,Dept Neurobio, Boston, MA 02115 USA

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2008年 / 52卷 / 5-6期

关键词：

CatSper; KSper; Ca2+; hyperactivated sperm motility; patch clamp; sperm; Ca2+ channel;

D O I：

10.1387/ijdb.072554bn

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are a Ca2+-selective current requiring expression of the 4 mCatSper genes, and a rectifying K+ current with properties most similar to mSIo3. Intracellular alkalinization activates both channels and induces hyperactivated motility.

引用

页码：607 / 613

页数：7

共 50 条

[1] Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyperpolarization during capacitation [J].

Arnoult, C ;

Kazam, IG ;

Visconti, PE ;

Kopf, GS ;

Villaz, M ;

Florman, HM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6757-6762

[2] CATSPER2, a human autosomal nonsyndromic male infertility gene [J].

Avidan, N ;

Tamary, H ;

Dgany, O ;

Cattan, D ;

Pariente, A ;

Thulliez, M ;

Borot, N ;

Moati, L ;

Barthelme, A ;

Shalmon, L ;

Krasnov, T ;

Asher, EB ;

Olender, T ;

Khen, M ;

Yaniv, I ;

Zaizov, R ;

Shalev, H ;

Delaunay, J ;

Fellous, M ;

Lancet, D ;

Beckmann, JS .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2003, 11 (07) :497-502

[3] Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3 [J].

Biel, M ;

Seeliger, M ;

Pfeifer, A ;

Kohler, K ;

Gerstner, A ;

Ludwig, A ;

Jaissle, G ;

Fauser, S ;

Zrenner, E ;

Hofmann, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) :7553-7557

[4] Identical phenotypes of CatSper1 and CatSper2 null sperm [J].

Carlson, AE ;

Quill, TA ;

Westenbroek, RE ;

Schuh, SM ;

Hille, B ;

Babcock, DF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (37) :32238-32244

[5] CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm [J].

Carlson, AE ;

Westenbroek, RE ;

Quill, T ;

Ren, DJ ;

Clapham, DE ;

Hille, B ;

Garbers, DL ;

Babcock, DF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (25) :14864-14868

[6] Abnormal coronary function in mice deficient in α1H T-type Ca2+ channels [J].

Chen, CC ;

Lamping, KG ;

Nuno, DW ;

Barresi, R ;

Prouty, SJ ;

Lavoie, JL ;

Cribbs, LL ;

England, SK ;

Sigmund, CD ;

Weiss, RM ;

Williamson, RA ;

Hill, JA ;

Campbell, KP .

SCIENCE, 2003, 302 (5649) :1416-1418

[7] Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor [J].

Chen, YQ ;

Cann, MJ ;

Litvin, TN ;

Iourgenko, V ;

Sinclair, ML ;

Levin, LR ;

Buck, J .

SCIENCE, 2000, 289 (5479) :625-628

[8] Sperm channel diversity and functional multiplicity [J].

Darszon, Alberto ;

Acevedo, Juan J. ;

Galindo, Blanca E. ;

Hernandez-Gonzalez, Enrique ;

Nishigaki, Takuya ;

Trevino, Claudia L. ;

Wood, Chris ;

Beltran, Carmen .

REPRODUCTION, 2006, 131 (06) :977-988

[9] Expression, localization and functions in acrosome reaction and sperm motility of cav3.1 and cav3.2 channels in sperm cells:: an evaluation from cav3.1 and cav3.2 deficient mice [J].

Escoffier, Jessica ;

Boisseau, Sylvie ;

Serres, Catherine ;

Chen, Chien-Chang ;

Kim, Daesoo ;

Stamboulian, Stverine ;

Shin, Hee-Sup ;

Campbell, Kevin P. ;

De Waard, Michel ;

Arnoult, Christophe .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 212 (03) :753-763

[10] Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect [J].

Esposito, G ;

Jaiswal, BS ;

Xie, F ;

Krajnc-Franken, MAM ;

Robben, TJAA ;

Strik, AM ;

Kuil, C ;

Philipsen, RLA ;

van Duin, M ;

Conti, M ;

Gossen, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2993-2998

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