Ion channels that control fertility in mammalian spermatozoa

被引：118

作者：

Navarro, Betsy ^{[1
]}

Kirichok, Yuriy ^{[1
]}

Chung, Jean-Ju ^{[1
]}

Clapham, David E. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst,Dept Cardiol,Dept Neurobio, Boston, MA 02115 USA

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2008年 / 52卷 / 5-6期

关键词：

CatSper; KSper; Ca2+; hyperactivated sperm motility; patch clamp; sperm; Ca2+ channel;

D O I：

10.1387/ijdb.072554bn

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are a Ca2+-selective current requiring expression of the 4 mCatSper genes, and a rectifying K+ current with properties most similar to mSIo3. Intracellular alkalinization activates both channels and induces hyperactivated motility.

引用

页码：607 / 613

页数：7

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