BAFF production by antigen-presenting cells provides T cell co-stimulation

被引:130
作者
Huard, B
Arlettaz, L
Ambrose, C
Kindler, V
Mauri, D
Roosnek, E
Tschopp, J
Schneider, P
French, LE
机构
[1] Univ Med Ctr, Dept Dermatol, CH-7211 Geneva 4, Switzerland
[2] Univ Hosp, Div Immunol & Allergol, CH-7211 Geneva, Switzerland
[3] Biogen Inc, Dept Gene Discovery, Cambridge, MA 02148 USA
[4] Univ Hosp, Div Hematol, CH-1211 Geneva, Switzerland
[5] Apotech Corp, CH-1066 Epalinges, Switzerland
[6] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland
关键词
antigen-presenting cell; co-stimulation; T cell; tumor necrosis factor;
D O I
10.1093/intimm/dxh043
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The B cell-activating factor from the tumor necrosis factor family (BAFF) is an important regulator of B cell immunity. Recently, we demonstrated that recombinant BAFF also provides a co-stimulatory signal to T cells. Here, we studied expression of BAFF in peripheral blood leukocytes and correlated this expression with BAFF T cell co-stimulatory function. BAFF is produced by antigen-presenting cells (APC). Blood dendritic cells (DC) as well as DC differentiated in vitro from monocytes or CD34(+) stem cells express BAFF mRNA. Exposure to bacterial products further up-regulates BAFF production in these cells. A low level of BAFF transcription, up-regulated upon TCR stimulation, was also detected in T cells. Functionally, blockade of endogenous BAFF produced by APC and, to a lesser extent, by T cells inhibits T cell activation. Altogether, this indicates that BAFF may regulate T cell immunity during APC-T cell interactions and as an autocrine factor once T cells have detached from the APC.
引用
收藏
页码:467 / 475
页数:9
相关论文
共 39 条
[21]   DENDRITIC CELLS FRESHLY ISOLATED FROM HUMAN BLOOD EXPRESS CD4 AND MATURE INTO TYPICAL IMMUNOSTIMULATORY DENDRITIC CELLS AFTER CULTURE IN MONOCYTE-CONDITIONED MEDIUM [J].
ODOHERTY, U ;
STEINMAN, RM ;
PENG, M ;
CAMERON, PU ;
GEZELTER, S ;
KOPELOFF, I ;
SWIGGARD, WJ ;
POPE, M ;
BHARDWAJ, N .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :1067-1078
[22]   An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein [J].
Pradet-Balade, B ;
Medema, JP ;
López-Fraga, M ;
Lozano, JC ;
Kolfschoten, GM ;
Picard, A ;
Martínez, C ;
Garcia-Sanz, JA ;
Hahne, M .
EMBO JOURNAL, 2002, 21 (21) :5711-5720
[23]   Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking [J].
Randolph, Gwendalyn J. ;
Beaulieu, Sylvie ;
Lebecque, Serge ;
Steinman, Ralph M. ;
Muller, William A. .
JOURNAL OF IMMUNOLOGY, 2017, 198 (11) :4191-4194
[24]   A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth [J].
Rennert, P ;
Schneider, P ;
Cachero, TG ;
Thompson, J ;
Trabach, L ;
Hertig, S ;
Holler, N ;
Qian, F ;
Mullen, C ;
Strauch, K ;
Browning, JL ;
Ambrose, C ;
Tschopp, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) :1677-1683
[25]  
Rolink AG, 2002, EUR J IMMUNOL, V32, P2004, DOI 10.1002/1521-4141(200207)32:7<2004::AID-IMMU2004>3.0.CO
[26]  
2-5
[27]   BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases [J].
Roschke, V ;
Sosnovtseva, S ;
Ward, CD ;
Hong, JS ;
Smith, R ;
Albert, V ;
Stohl, W ;
Baker, KP ;
Ullrich, S ;
Nardelli, B ;
Hilbert, DM ;
Migone, TS .
JOURNAL OF IMMUNOLOGY, 2002, 169 (08) :4314-4321
[28]  
Salmon P, 2001, J GENE MED, V3, P311, DOI 10.1002/1521-2254(200107/08)3:4<311::AID-JGM198>3.0.CO
[29]  
2-B
[30]   G-CSF-stimulated neutrophils are a prominent source of functional BLyS [J].
Scapini, P ;
Nardelli, B ;
Nadali, G ;
Calzetti, F ;
Pizzolo, G ;
Montecucco, C ;
Cassatella, MA .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (03) :297-302