Neutral Ti catalysts for the intramolecular hydroamination of alkenes

被引:73
作者
Mueller, Carsten [1 ]
Loos, Christian [1 ]
Schulenberg, Nikola [1 ]
Doye, Sven [1 ]
机构
[1] Univ Heidelberg, Organ Chem Inst, D-69120 Heidelberg, Germany
关键词
alkenes; amines; homogeneous catalysis; hydroamination; titanium;
D O I
10.1002/ejoc.200600115
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Neutral titanium complexes are well known precatalysts for the inter- and intramolecular hydroamination of alkynes. In this publication, we show the capability of several neutral titanium complexes to catalyze intramolecular hydroamination reactions of alkenes. The corresponding pyrrolidine and piperidine products are formed in yields up to 97%. Among the substrates used, only geminally disubstituted amino alkenes are successfully cyclized.
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页码:2499 / 2503
页数:5
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