Intramolecular hydroamination of unactived olefins with Ti(NMe2)4 as a precatalyst

被引：190

作者：

Bexrud, JA ^{[1
]}

Beard, JD ^{[1
]}

Leitch, DC ^{[1
]}

Schafer, LL ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 10期

关键词：

D O I：

10.1021/ol0503992

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Commercially available Ti(NMe2)(4) has been used effectively as a precatalyst in a facile protocol for the intramolecular hydroamination of aminoalkenes to yield pyrrolidine and piperidine heterocyclic products with isolated yields up to 92%. Germinally substituted substrates display the highest reactivity. This precatalyst is also effective for the hydroamination of activated internal alkenes, providing access to more complex heterocyclic target molecules.

引用

页码：1959 / 1962

页数：4

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