Exploiting LH in ovarian stimulation

被引：44

作者：

Alviggi, C ^{[1
]}

Mollo, A ^{[1
]}

Clarizia, R ^{[1
]}

De Placido, G ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Sci Ostet Ginecol Urol & Med Riprod, I-80131 Naples, Italy

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2006年 / 12卷 / 02期

关键词：

assisted reproductive techniques; ceiling; LH; ovarian stimulation; recombinant gonadotrophin; threshold;

D O I：

10.1016/S1472-6483(10)60865-6

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

During intermediate-late phases of human folliculogenesis, LH plays a key role in promoting steroidogenesis and growth of the leading follicle. Ovarian stimulation for assisted reproduction techniques usually consists of administering exogenous FSH in a low LH environment. Although an impairment in LH-dependent paracrine activities would be expected, multiple follicular growth is efficiently achieved in almost all patients. Thus, there appears to be a discrepancy between classical foilliculogenesis models and data from IVF. This study examines the 'interface' between basic endocrinological and clinical evidence, in an attempt to answer two questions: is there an LH therapeutic window, and if there is, how can this be exploited in the practice of assisted reproduction? It also reviews the evidence that specific subgroups of women may benefit from LH supplementation during ovarian stimulation.

引用

页码：221 / 233

页数：13

共 77 条

[71] Human menopausal gonadotropin versus recombinant follicle-stimulating hormone in normogonadotropic women down-regulated with a gonadotropin-releasing hormone agonist who were undergoing in vitro fertilization and intracytoplasmic sperm injection: a prospective randomized study [J].