Mechanism of colchicine impairment on learning and memory, and protective effect of CGP(36742) in mice

被引：32

作者：

Yu, ZF

Cheng, GJ

Hu, BR

机构：

[1] SUN YAT SEN UNIV, DEPT PHARMACOL, GUANGZHOU 510089, PEOPLES R CHINA

[2] SUN YAT SEN UNIV, INST CANC, GUANGZHOU 510089, PEOPLES R CHINA

来源：

BRAIN RESEARCH | 1997年 / 750卷 / 1-2期

关键词：

colchicine; learning; memory; glutamate; GABA; GABA(B) receptor; GABA(B) receptor antagonist; Alzheimer's disease;

D O I：

10.1016/S0006-8993(96)01158-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fourteen days after hippocampal microinfusion with colchicine (COL), learning and memory ability of mice was significantly impaired, while glutamate (Glu), gamma-aminobutyric acid (GABA), Glu/GABA and GABAB receptor levels in the cortex and/or the hippocampus were significantly changed. After treatment with a GABA(B) receptor antagonist, CGP(36742) learning and memory impairment caused by COL could be significantly improved, and the above indices in brain regions reversed. These results suggest GABA(B) antagonists may have therapeutic value in the treatment of Alzheimer's disease. (C) 1997 Elsevier Science B.V. All rights reserved.

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页码：53 / 58

页数：6

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