Memory enhancement by the angiotensinergic system in the crab Chasmagnathus is mediated by endogenous angiotensin II

被引：27

作者：

Delorenzi, A ^{[1
]}

Maldonado, H ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Lab Neurobiol Memoria, Dept Biol, RA-1428 Buenos Aires, DF, Argentina

来源：

NEUROSCIENCE LETTERS | 1999年 / 266卷 / 01期

关键词：

angiotensin II; angiotensin IV; dival; neuropeptides; crab; memory;

D O I：

10.1016/S0304-3940(99)00232-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In previous work with the crab Chasmagnathus, it was reported that either exogenous angiotensin II (ANGII) or angiotensin IV (ANGIV), have an enhancing effect on long-term memory, which involves an association between context and an iterative danger stimulus (context-signal memory, CSM). Present results indicate that Dival, an ANGIV antagonist, reverts the facilitatory effect of ANGIV but not that of ANGII, whereas saralasin but not Dival, disrupts CSM. These findings suggest that ANGII is the endogenous angiotensin that plays a significant role in long-term memory, while the ANGIV receptor would not be encompassed in the cascade of events related to crab's CSM. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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页码：1 / 4

页数：4

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