Optimal intracellular calcium signaling

被引：155

作者：

Shuai, JW ^{[1
]}

Jung, P

机构：

[1] Ohio Univ, Dept Phys & Astron, Athens, OH 45701 USA

[2] Ohio Univ, Inst Quantitat Biol, Athens, OH 45701 USA

来源：

PHYSICAL REVIEW LETTERS | 2002年 / 88卷 / 06期

关键词：

D O I：

10.1103/PhysRevLett.88.068102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

In many cell types, calcium is released from internal stores through calcium release channels upon external stimulation (e.g., pressure or receptor binding), These channels are clustered with a typical cluster size of about 20 channels, generating stochastic calcium puffs, We find that the clustering of the release channels in small clusters increases the sensitivity of the calcium response, allowing for coherent calcium responses at signals to which homogeneously distributed channels would not respond.

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页数：4

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