Calcium Phosphate Nanocomposite Particles for In Vitro Imaging and Encapsulated Chemotherapeutic Drug Delivery to Cancer Cells

被引：384

作者：

Kester, Mark ^{[2
]}

Heakal, Yasser ^{[2
]}

Fox, Todd ^{[2
]}

Sharma, Arati ^{[2
]}

Robertson, Gavin P. ^{[2
]}

Morgan, Thomas T. ^{[1
]}

Altinoglu, Erhan I. ^{[1
]}

Tabakovic, Amra ^{[1
]}

Parette, Mylisa R. ^{[1
]}

Rouse, Sarah M. ^{[1
]}

Ruiz-Velasco, Victor ^{[2
]}

Adair, James H. ^{[1
]}

机构：

[1] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA

[2] Penn State Coll Med, Hershey, PA 17033 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 12期

基金：

美国国家航空航天局; 美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1021/nl802098g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Paradigm-shifting modalities to more efficiently deliver drugs to cancerous lesions require the following attributes: nanoscale-size, targetability, and stability under physiological conditions. Often, these nanoscale drug delivery vehicles are limited due to agglomeration, poor solubility, or cytotoxicity. Thus, we have designed a methodology to encapsulate hydrophobic antineoplastic chemotherapeutics within a 20-30 nm diameter, pH-responsive, nonagglomerating, nontoxic calcium phosphate nanoparticle matrix. In the present study, we report on calcium phosphate nanocomposite particles (CPNPs) that encapsulate both fluorophores and chemotherapeutics, are colloidally stable in physiological solution for an extended time at 37 degrees C and can efficaciously deliver hydrophobic antineoplastic agents, such as ceramide, in several cell model systems.

引用

页码：4116 / 4121

页数：6

共 43 条

[11]

COE FL, 1996, KIDNEY STONES MED SU, P1109

[12] The clinical potential of sphingolipid-based therapeutics [J].

Fox, T. E. ;

Finnegan, C. M. ;

Blumenthal, R. ;

Kester, M. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (09) :1017-1023

[13]

Freshney R.I., 1994, Culture of Animal Cells, VThird, P486, DOI [DOI 10.1128/genomeA.00048-15, 10.1002/cbf.646, DOI 10.1002/CBF.646]

[14]

Funk J.E., 1994, PREDICTIVE PROCESS C

[15] Glycosphingolipids and drug resistance [J].

Gouaze-Andersson, Valerie ;

Cabot, Myles C. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (12) :2096-2103

[16] Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification [J].

Hoshino, A ;

Fujioka, K ;

Oku, T ;

Suga, M ;

Sasaki, YF ;

Ohta, T ;

Yasuhara, M ;

Suzuki, K ;

Yamamoto, K .

NANO LETTERS, 2004, 4 (11) :2163-2169

[17]

Hunter R. J., 1988, Zeta Potential in Colloid Science, Principles and Applications, VThird

[18] Potentials and pitfalls of fluorescent quantum dots for biological imaging [J].

Jaiswal, JK ;

Simon, SM .

TRENDS IN CELL BIOLOGY, 2004, 14 (09) :497-504

[19] Formation of calcium phosphate nanoparticles in reverse microemulsions [J].

Lai, C ;

Tang, SQ ;

Wang, YJ ;

Wei, K .

MATERIALS LETTERS, 2005, 59 (2-3) :210-214

[20] Preparation of Ag/SiO2 nanosize composites by a reverse micelle and sol-gel technique [J].

Li, T ;

Moon, J ;

Morrone, AA ;

Mecholsky, JJ ;

Talham, DR ;

Adair, JH .

LANGMUIR, 1999, 15 (13) :4328-4334

← 1 2 3 4 5 →