Teratology of retinoids

被引：217

作者：

Collins, MD ^{[1
]}

Mao, GE ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90095 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 1999年 / 39卷

关键词：

retinoic acid; retinoid receptor; vitamin A; dysmorphogenesis; embryogenesis;

D O I：

10.1146/annurev.pharmtox.39.1.399

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Either an excess or a deficiency of vitamin A and related compounds (retinoids) causes abnormal morphological development (teratogenesis). Potential retinoid sources come from dietary intake, nutritional supplements, and some therapeutic drugs. Therefore, understanding the mechanisms of retinoid teratogenesis is important. This review first gives an overview of the principles of teratology as they apply to retinoid-induced malformations. It then describes relevant aspects of the biochemical pathway and signal transduction of retinoids. The teratogenic activity of various retinoid compounds, the role of the retinoid receptors, and important toxicokinetic parameters in teratogenesis an reviewed.

引用

页码：399 / 430

页数：32

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