Isolated populations and complex disease gene identification

被引：105

作者：

Kristiansson, Kati ^{[1
,2
]}

Naukkarinen, Jussi ^{[1
,3
]}

Peltonen, Leena ^{[1
,2
,3
]}

机构：

[1] Inst Mol Med, Natl Publ Hlth Inst, Helsinki 00300, Finland

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[3] Univ Helsinki, Dept Med Genet, FIN-00014 Helsinki, Finland

来源：

GENOME BIOLOGY | 2008年 / 9卷 / 08期

关键词：

D O I：

10.1186/gb-2008-9-8-109

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The utility of genetically isolated populations (population isolates) in the mapping and identification of genes is not only limited to the study of rare diseases; isolated populations also provide a useful resource for studies aimed at improved understanding of the biology underlying common diseases and their component traits. Well characterized human populations provide excellent study samples for many different genetic investigations, ranging from genome-wide association studies to the characterization of interactions between genes and the environment.

引用

页数：9

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