Prognostic significance of smac/DIABLO in endometrioid endometrial cancer

被引：12

作者：

Dobrzycka, Bozena ^{[1
]}

Terlikowski, Slawomir J. ^{[1
]}

Bernaczyk, Piotr S. ^{[2
]}

Garbowicz, Magdalena ^{[3
]}

Niklinski, Jacek ^{[3
]}

Chyczewski, Lech ^{[2
]}

Kulikowski, Marek ^{[4
]}

机构：

[1] Med Univ Bialystok, Dept Obstet Gynecol & Obstet Gynecol Care, PL-15062 Bialystok, Poland

[2] Med Univ Bialystok, Dept Pathomorphol, PL-15062 Bialystok, Poland

[3] Med Univ Bialystok, Dept Clin Mol Biol, PL-15062 Bialystok, Poland

[4] Med Univ Bialystok, Dept Perinatol, PL-15062 Bialystok, Poland

来源：

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2010年 / 48卷 / 04期

关键词：

endometrioid endometrial cancer; smac/DIABLO; prognosis;

D O I：

10.2478/v10042-010-0091-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrial pathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examined smac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantified by Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors. Smac/DIABLO expression significantly correlated with tumor grade (p<0.001). Patients with positive smac/DIABLO tumors had a longer disease-specific survival when compared with those with negative tumors in the 10-year follow-up (p=0.043). The study demonstrated that negative smac/DIABLO expression was a poor prognostic sign.

引用

页码：678 / 681

页数：4

共 21 条

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[2]

High Smac/DIABLO expression is associated with early local recurrence of cervical cancer [J].