Siglecs as positive and negative regulators of the immune system

被引：115

作者：

Crocker, Paul R. ^{[1
]}

Redelinghuys, Pierre ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, Div Cell Biol & Immunol, Dundee DD1 5EH, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

innate immune system; lectin; myeloid; pathogen; sialic acid; siglec;

D O I：

10.1042/BST0361467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Siglecs (sialic acid-binding lg-like lectins) are mainly expressed in the immune system. Sn (sialoadhesin) (siglec-1), CD22 (siglec-2) and siglec-15 are well conserved, whereas the CD33-related siglecs are undergoing rapid evolution, as reflected in large differences in repertoires among the different mammals studied so far. In the present paper, we review recent findings on the signalling properties of the CD33-related siglecs and discuss the emergence of both inhibitory and activating forms of this family. We also discuss how Sn may function as a positive regulator of adaptive immune responses and its emerging role as an induced macrophage pattern-recognition molecule for sialylated pathogens, especially enveloped viruses.

引用

页码：1467 / 1471

页数：5

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