Genetics and biology of pancreatic ductal adenocarcinoma

被引:886
作者
Hezel, Aram F.
Kimmelman, Alec C.
Stanger, Ben Z.
Bardeesy, Nabeel
DePinho, Ronald A.
机构
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dana Farber Canc Inst,Dept Med, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Radiat Oncol Program, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Genet, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Dana Farber Canc Inst, Gastrointestinal Unit, Boston, MA 02115 USA
[6] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med,Dana Farber Canc Inst, Boston, MA 02114 USA
[7] Harvard Univ, Sch Med, Ctr Appl Canc Sci, Dana Farber Canc Inst, Boston, MA 02114 USA
[8] Harvard Univ, Sch Med, Belfer Inst Innovat Canc Sci, Dana Farber Canc Inst, Boston, MA 02114 USA
关键词
D O I
10.1101/gad.1415606
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of < 6 mo and a dismal 5-yr survival rate of 3%-5%. The cancer's lethal nature stems from its propensity to rapidly disseminate to the lymphatic system and distant organs. This aggressive biology and resistance to conventional and targeted therapeutic agents leads to a typical clinical presentation of incurable disease at the time of diagnosis. The well-defined serial histopathologic picture and accompanying molecular profiles of PDAC and its precursor lesions have provided the framework for emerging basic and translational research. Recent advances include insights into the cancer's cellular origins, high-resolution genomic profiles pointing to potential new therapeutic targets, and refined mouse models reflecting both the genetics and histopathologic evolution of human PDAC. This confluence of developments offers the opportunity for accelerated discovery and the future promise of improved treatment.
引用
收藏
页码:1218 / 1249
页数:32
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