Sensing NAD metabolites through macro domains

被引：48

作者：

Till, Susanne ^{[1
]}

Ladurner, Andreas G. ^{[1
]}

机构：

[1] European Mol Biol Lab, Gene Express Unit, Struct & Computat Biol Unit, Meyerhofstr 1, D-69117 Heidelberg, Germany

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷

关键词：

Gene Expression; ADP-ribose; NAD; Sirtuins; PARP; Metabolites; Review; INACTIVE X-CHROMOSOME; HISTONE VARIANT MACROH2A; POLY(ADP-RIBOSE) POLYMERASE-ACTIVITY; B-CELL LYMPHOMAS; ADP-RIBOSE; STRUCTURAL-CHARACTERIZATION; HETEROCHROMATIN FOCI; GENE-EXPRESSION; MOUSE EMBRYOS; CORE HISTONE;

D O I：

10.2741/3448

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The macro module is a globular protein domain of about 25 kDa that is evolutionarily conserved in organisms from viruses, bacteria, yeast to humans. It is generally part of proteins that have wide-ranging (and yet to be discovered) cellular functions. There are several examples of macro domains associated with modules showing homology to poly-ADP-ribosyl-polymerases. Many macro domains, including those of the human histone macroH2A1.1, bind NAD metabolites such as ADP-ribose, suggesting that macro domains may function in the recognition of this and related molecules. The presence of a metabolite-binding function in a repressive chromatin component opens new potential connections between chromosome structure, gene silencing and cellular metabolism. Current evidence suggests that macro domains also represent a novel tool for studying NAD metabolites and may be an attractive drug target for the treatment of diseases.

引用

页码：3246 / 3258

页数：13

共 69 条

[11] Histone variant macroH2A contains two distinct macrochromatin domains capable of directing macroH2A to the inactive X chromosome [J].