Lipophilicity profiles: Theory and measurement

被引：98

作者：

Comer, J ^{[1
]}

Tam, K ^{[1
]}

机构：

[1] Sirius Analyt Instruments Ltd, Forest Row RH18 5HE, E Sussex, England

来源：

PHARMACOKINETIC OPTIMIZATION IN DRUG RESEARCH: BIOLOGICAL, PHYSICOCHEMICAL, AND COMPUTATIONAL STRATEGIES | 2001年

关键词：

D O I：

10.1002/9783906390437.ch17

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：275 / 304

页数：30

共 57 条

[1] Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs [J].

Allen, RI ;

Box, KJ ;

Comer, JEA ;

Peake, C ;

Tam, KY .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1998, 17 (4-5) :699-712

[2]

[Anonymous], COMMUNICATION

[3] PH-METRIC LOG-P .1. DIFFERENCE PLOTS FOR DETERMINING ION-PAIR OCTANOL-WATER PARTITION-COEFFICIENTS OF MULTIPROTIC SUBSTANCES [J].

AVDEEF, A .

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, 1992, 11 (04) :510-517

[4] ACCURATE MEASUREMENTS OF CONCENTRATION OF HYDROGEN-IONS WITH A GLASS-ELECTRODE - CALIBRATIONS USING PRIDEAUX AND OTHER UNIVERSAL BUFFER SOLUTIONS AND A COMPUTER-CONTROLLED AUTOMATIC TITRATOR [J].

AVDEEF, A ;

BUCHER, JJ .

ANALYTICAL CHEMISTRY, 1978, 50 (14) :2137-2142

[5] PH-METRIC LOG-P .2. REFINEMENT OF PARTITION-COEFFICIENTS AND IONIZATION-CONSTANTS OF MULTIPROTIC SUBSTANCES [J].

AVDEEF, A .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1993, 82 (02) :183-190

[6]

Avdeef A., 1996, LIPOPHILICITY DRUG A, P109

[7]

BARBATO F, 1990, FARMACO, V45, P647

[8]

Box K. J., 2000, HIGH THROUGHPUT SCRE, P67

[9] Lipophilicity behavior of model and medicinal compounds containing a sulfide, sulfoxide, or sulfone moiety [J].

Caron, G ;

Gaillard, P ;

Carrupt, PA ;

Testa, B .

HELVETICA CHIMICA ACTA, 1997, 80 (02) :449-462

[10] Combined molecular lipophilicity descriptors and their role in understanding intramolecular effects [J].

Caron, G ;

Reymond, F ;

Carrupt, PA ;

Girault, HH ;

Testa, B .

PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY, 1999, 2 (08) :327-335

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