Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase α and β

被引：33

作者：

Akihisa, T

Mizushina, Y

Ukiya, M

Oshikubo, M

Kondo, S

Kimura, Y

Suzuki, T

Tai, T

机构：

[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan

[2] Kobe Gakuin Univ, Dept Nutr Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan

[3] Kotaro Pharmaceut Co Ltd, Cent Res Lab, Takatsuki, Osaka 5690022, Japan

[4] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan

[5] Morishita Jintan Co Ltd, Chuo Ku, Osaka 5408566, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 02期

关键词：

Poria cocos; triterpene acids; dehydrotrametenonic acid; dehydroeburiconic acid; DNA polymerase inhibitory effect;

D O I：

10.1271/bbb.68.448

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new lanostane-type triterpene acid, (20xi)-3-oxolanosta-7,9(11),24-trien-21-oic acid (1; dehydrotrametenonic acid), along with a known triterpene acid, dehydroeburiconic acid (2), were isolated from the epidermis of the sclerotia of Poria cocos. The structure of 1 was analyzed on the basis of spectroscopic methods. Compounds 1 and 2 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with the 50% inhibition values of 45.5 muM (1) and 40.8 muM (2), and 86.5 muM (1) and 30.0 muM (2), respectively.

引用

页码：448 / 450

页数：3

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