Eupha-7,9(11),24-trien-3β-ol ("Antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation

被引：52

作者：

Akihisa, T

Wijeratne, EMK

Tokuda, H

Enjo, F

Toriumi, M

Kimura, Y

Koike, K

Nikaido, T

Tezuka, Y

Nishino, H

机构：

[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan

[2] Kyoto Prefectural Univ Med, Dept Biochem, Med Res Inst, Div Nat Prod Chem, Kyoto 6020841, Japan

[3] Nihon Univ, Coll Pharm, Chiba 2748555, Japan

[4] Toho Univ, Sch Pharmaceut Sci, Chiba 2748510, Japan

[5] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku, Toyama 9300194, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 02期

关键词：

D O I：

10.1021/np010377y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The structures of three triterpene alcohols isolated from the latex of Euphorbia antiquorum were established to be eupha-7,9(11),24-trien-3beta-ol (2; antiquol C), 19(10-->9)abeo-8alpha,9,10alpha-eupha-5,24-dien-3beta-ol (3; antiquol B), and 24-methyltirucalla-8,24(24(1))-dien-3beta-ol (4; euphorbol) on the basis of spectroscopic methods. Compounds 3 and 4 have previously been assigned the erroneous structures of 10alpha-cucurbita-5,24-dien-3alpha-ol and 24-methyleupha-8,24(24(1))-dien-3beta-ol, respectively. Compounds 2-4 and four other known compounds isolated from the latex, euphol (1), lemmaphylla-7,21-dien-3beta-ol (5), isohelianol (6), and camelliol C (7), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

引用

页码：158 / 162

页数：5

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