Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells

被引:175
作者
Weinberg, A
Belton, CM
Park, Y
Lamont, RJ
机构
[1] UNIV WASHINGTON,DEPT ORAL BIOL,SEATTLE,WA 98195
[2] UNIV WASHINGTON,DEPT PERIODONT,SEATTLE,WA 98195
关键词
D O I
10.1128/IAI.65.1.313-316.1997
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Porphyromonas gingivalis is a periodontal pathogen capable of invading primary cultures of normal human gingival epithelial cells (NHGEC), Involvement of P. gingivalis fimbriae in the invasion process was examined, Purified P. gingivalis 33277 fimbriae blocked invasion of this organism into NHGEC in a dose-dependent manner. DPG3, a P. gingivalis fimbria-deficient mutant, was impaired in its invasion capability approximately eightfold compared to its parent, strain 381, However, adherence of the mutant was only 50% reduced compared to the parent, Biotin labeling of NHGEC surface proteins revealed that two fimbriated strains, but not DPG3, bound a 48-kDa NHGEC protein, Adhesin-receptor interactions, such as fimbriae binding to a 48-kDa NHGEC surface receptor, may trigger activation of eukaryotic proteins involved in signal transduction and/or provoke the generation of surface P. gingivalis molecules required for internalization.
引用
收藏
页码:313 / 316
页数:4
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