Molecular mechanisms of drug inhibition of DNA gyrase

被引:61
作者
Lewis, RJ [1 ]
Tsai, FTF [1 ]
Wigley, DB [1 ]
机构
[1] UNIV OXFORD, MOL BIOPHYS LAB, OXFORD OX1 3QU, ENGLAND
关键词
D O I
10.1002/bies.950180810
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X-ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA gyrase.
引用
收藏
页码:661 / 671
页数:11
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